Berberine: siv, txiaj ntsig, ntxiv thiab cov teebmeem

Berberine muaj keeb kwm ntev ntawm kev siv hauv cov tshuaj siv tshuaj, xws liAyurvedathiab East Asian tshuaj. Nws yog ib qho iab-tasting tshuaj compound tau los ntawm ntau yam nroj tsuag, xws li hydrastis canadensis (goldenseal), coptis chinensis (coptis los yog goldenthread) thiab berberis vulgaris (barberry). Kev tshawb fawb qhia tias berberine tuaj yeem muaj cov tshuaj tua kab mob thiab tshuaj tua kab mob, nrog rau cov txiaj ntsig zoo ntawm cov metabolism, tab sis xav tau kev sim tshuaj ntxiv kom paub meej tias cov txiaj ntsig no.

Berberine kuj tseem tuaj yeem muaj ntau yam txiaj ntsig ntawm lub cev thiab cov tshuaj ua haujlwm hauv lub siab, lub raum, lub plawv thiab lub hlwb, muaj peev xwm muab kev txhawb nqa ntxiv hauv metabolic. Piv txwv li, berberine activates lub enzyme AMP-activated protein kinase, uas kev tshawb fawb qhia tias pab tswj cov metabolism, cell ua haujlwm thiab qib zog.

Berberine feem ntau yog siv los pabtxo cov ntshav qab zib, txhim kho cov hlab plawv kev noj qab haus huv, txo oxidative kev nyuaj siab thiabtxo cov roj cholesterolHeather Zwickey, Ph.D, xibfwb ntawm kev tiv thaiv kab mob hauv National University of Natural Medicine hauv Portland, Oregon, thiab rau nws cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob thiab tiv thaiv kab mob cancer.

Berberine feem ntau pom muaj nyob rau hauv daim ntawv tshuaj ntsiav, tab sis nws kuj yog tsim los ua qhov muag tee thiab gels rau ntau yam mob ntawm daim tawv nqaij, qhov muag lossis pob qij txha.

Ntau cov nroj tsuag thiab tshuaj ntsuab uas muaj berberine tau siv tshuaj rau ntau txhiab xyoo, tseem xav tau kev tshawb fawb ntxiv kom nkag siab txog cov txheej txheem ntawm kev ua haujlwm thiab cov txiaj ntsig ntev. Nrog rau qhov hais tias, kev tshawb fawb qhia tias nws yuav muaj txiaj ntsig zoo rau ib tus neeg noj qab haus huv ntau txoj hauv kev.

Tej zaum yuav pab txo qis cov piam thaj hauv cov ntshav thiab tiv thaiv insulin tsis kam

A 2022 tshuaj xyuas hauvMoleculesqhia tau hais tias berberine tuaj yeem pab tautxo cov ntshav qabzibvim tias nws nce insulin ntau lawm thiab txhim kho insulin rhiab heev, txawm tias xav tau kev tshawb fawb ntxiv kom nkag siab txog cov teebmeem no[1].

Tej zaum yuav pab txo cov roj cholesterol

Kev tshawb fawb qhia tias berberine yuav muaj txiaj ntsig zoo rauLDL cov cholesterolthiab tag nrho cov roj (cholesterol) tag nrho, txawm tias yuav tsum muaj kev sim tshuaj ntxiv kom nkag siab txog qhov kev thov kev noj qab haus huv no tag nrho.

Tej zaum Yuav Txhim Kho Kab Mob Ntshav Qab Zib

Berberine tuaj yeem muaj txiaj ntsig zoo rau cov ntaub so ntswg plawv, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob ischemia (cov ntshav tsis txaus), los ntawm kev txhim kho cov leeg nqaij lub zog, txo qhov mob, txo cov oxidative kev nyuaj siab, txo cov ntshav siab thiab ua kom lub plawv dhia.

Tej zaum muaj Anti-Inflammatory Effects

Berberine yog ib qho alkaloid iab uas muab cov kab mob los tiv thaiv kab mob, hais tias Alicia McCubbins, kws kho mob naturopathic nyob hauv Vancouver, Washington. Cov khoom no tuaj yeem muaj txiaj ntsig zoo rau tag nrho cov txheej txheem metabolic, xws li muaj peev xwm pab tiv thaiv atherosclerosis, ntshav qab zib hom 2, rog rog thiab mob plawv. Berberine's anti-inflammatory zog tau kawm ntev, tab sis nws cov txheej txheem ntawm kev txiav txim tseem tsis tau to taub, qhia txog qhov xav tau kev tshawb fawb ntxiv.

Tej zaum muaj Antioxidant Properties

Ib 2018 review inFrontiers hauv Pharmacologyxaus lus tias berberine cov teebmeem antioxidant yog piv rau cov vitamin C, muaj zog antioxidant.[2]. Cov tshuaj xws li vitamin C thiab berberine ua raws li antioxidants los pab kom tsis txhob muaj kev puas tsuaj dawb radicals tuaj yeem ua rau cov hlwb.

Tej zaum muaj Antibacterial thiab Antimicrobial Properties

"Berberine muaj astringent zog thiab raug suav hais tias yog ib tug natural antimicrobial uas muaj peev xwm tshem tawm cov kab mob, parasites thiab fungi/candida," qhia Dr. McCubbins. Cov khoom siv tshuaj tua kab mob no tuaj yeem pab txhim kho qee yam mob, xws li mob hnyavraws plab, kab mob dysentery, jaundice thiab kab mob hauv qhov chaw mos, txawm tias xav tau kev tshawb fawb ntxiv los txhawb cov lus thov no. Yog tias ib tus neeg ntseeg tias lawv muaj kab mob ntawm txhua yam, lawv yuav tsum sab laj nrog lawv tus kws kho mob kom kuaj xyuas thiab kho kom raug ua ntej noj berberine lossis lwm yam ntxiv.

Tej zaum yuav txhim kho digestive Health

Berberine tuaj yeem muaj txiaj ntsig zoo rau kev noj qab haus huv, xws li cem quav thiabmob plawv, raws li Dr. McCubbins. "Cov alkaloids no tuaj yeem muab cov txiaj ntsig zoo rau kev sib txuas ntawm plab-hlwb," nws hais ntxiv, hais txog qhov tseem ceeb ntawm kev sib txuas ntawm kev zom zaub mov, kev xav thiab kev noj qab haus huv tag nrho.

Tej zaum yuav txhawb kev poob phaus thiab tswj qhov hnyav

Berberine tuaj yeem pab txo cov rog thiab piam thaj los ntawm kev txhim kho cov txheej txheem metabolic, xws li kev tawg ntawm lipids (rog) thiab suab thaj, kev tshawb fawb qhia. Berberines 'kev cuam tshuam zoo rau lub plab microbiome kuj tseem yog qhov tseem ceeb hauv nws txoj kev txhawb nqa ntawm kev tswj qhov hnyav.

Tej zaum yuav txhim kho cov tsos mob ntawm Polycystic Ovarian Syndrome (PCOS) thiab Ovulation

Raws li kev txheeb xyuas hauvMolecules, noj 1,500 milligrams ntawm berberine ib hnub rau peb lub hlis txo qis testosterone qib hauv cov poj niam nrogPCOS[3]. Tus mob no tuaj yeem cuam tshuam txog kev tsim cov tshuaj hormones txawv txav thiab ua rau muaj ntau yam tsis sib xws, ua rau muaj teeb meem xws li cov hlwv me me ntawm zes qe menyuam lossis kev coj khaub ncaws txawv txav. Cov kws tshaj lij kuj ntseeg tias berberine txhim kho insulin tsis kam, uas yog ib qho ntawm PCOS. Txawm li cas los xij, cov kws tshawb fawb tau hais tias yuav tsum muaj kev sim tshuaj ntxiv kom paub meej tias qhov cuam tshuam ntawm berberine, nrog rau kev kho ntev ntev thiab kev siv tshuaj kho mob.

 

Yuav Siv Li Cas Berberine?

Cov tshuaj Berberine muaj nyob rau hauv cov tshuaj ntsiav, ntsiav tshuaj lossis daim ntawv tincture, uas tso cai rau kev txhaj tshuaj thiab noj tau yooj yim. Cov tshuaj ntsiav tej zaum yuav zoo dua rau cov neeg siv khoom feem ntau muab nws cov saj iab heev, piav qhia Dr. McCubbins. "Berberine feem ntau yog siv los ua lub plab zom mov 5 mus rau 30 feeb ua ntej noj mov. Berberine yog ib txwm iab uas ua rau lub plab zom mov kom ua haujlwm tau zoo dua, "nws hais ntxiv.

Berberine Dosage

Cov tib neeg yuav tsum sab laj nrog kws kho mob lossis kws kho mob los tham txog kev noj tshuaj kom raug (uas tsis yog tus qauv), thiab nyeem cov chaw tsim khoom cov lus qhia, hais tias Dr. Zwickey. "Nws feem ntau suav tias muaj kev nyab xeeb hauv [txhua hnub] koob tshuaj [tsis pub ntau tshaj] 2 grams. Txhawm rau [ua tiav cov txiaj ntsig zoo], ib tus neeg yuav xav siv tsawg kawg 1 gram (1000 milligrams) ib hnub. Feem ntau cov tshuaj [muaj] 500 milligrams ib capsule, yog li ib tug neeg xav noj [tsawg kawg ob] tshuaj ntsiav ib hnub, "nws hais ntxiv.

Berberine ntau npaum li cas yuav nyob ntawm tus neeg lub hom phiaj kev noj qab haus huv. Hais txog ntshav qab zib, 2019 kev tshuaj xyuas zoo thiab ntsuas ntsuas hauv qhovEndocrine Journalpom tias noj qis dua 2 grams ntawm berberine ib hnub rau peb lub hlis tau cuam tshuam cov ntshav qabzib ntau ntawm cov neeg mob ntshav qab zib hom 2.[4].

Lub caij no, kev tshuaj xyuas ntawm cov kev tshawb fawb muaj nyob hauvComplementary Therapies hauv Clinical Practicetshuaj xyuas cov tshuaj teb ntawm berberine extract rau cov neeg rog rog thiab nrhiav kev tswj qhov hnyav, pom tias koob tshuaj 500 milligrams noj peb zaug hauv ib hnub ua rau txo qis.Lub cev qhov hnyav (BMI), lub duav ncig thiab lub cev hnyav[5].

Berberine Side Effects

Cov tshuaj Berberine tuaj yeem muaj qee yam kev mob tshwm sim, suav nrog raws plab, mob plab thiab mob taub hau, hais tias Dr. McCubbins.

"Berberine tau nce hauv kev muaj koob npe thiab ua lag luam hnyav rau lub zej zog poob," nws hais ntxiv. "Cia li ceev faj thiab sab laj tus kws kho mob naturopathic txog [tus] kev siv tshuaj kho [ntawm berberine ua ntej noj nws]."

Thaum berberine feem ntau zam tau zoo, nws yuav ua rau mob plab thiab mob plab, cem quav, raws plab, flatulence, xeev siab thiab ntuav, ntxiv Dr. Zwickey.

Puas yog Berberine Safe?

Qhov kev txhawj xeeb tseem ceeb ntawm kev nyab xeeb ntawm berberine yog tias nws tuaj yeem cuam tshuam nrog ntau yam tshuaj, hais tias Dr. Zwickey. Qhov kev cuam tshuam loj tshaj plaws yog nrog cyclosporine, ib qho tshuaj tiv thaiv kab mob siv tom qab hloov khoom nruab nrog cev thiab pab tswj cov kab mob autoimmune xws limob caj dab rheumatoid, raws li berberine nce qhov concentration ntawm cyclosporine hauv cov ntshav, nws piav qhia.

Txawm hais tias tus neeg siv berberine los ua ib qho tshuaj ntxiv los yog ib hom tshuaj ntsuab tag nrho, nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov lus qhia pom zoo los ntawm cov chaw tsim khoom lossis cov kws kho mob. Berberine yog contraindicated rau cov me nyuam, nrog rau cov poj niam cev xeeb tub thiab lactating neeg, sau tseg Dr. Zwickey.

Dab tsi los xav txog thaum yuav Berberine?

Vim hais tias feem ntau manufacturers purify berberine los ntawm ib tsob nroj, peb-tog kuaj kuaj rau tus kheej ntawm berberine, lub zog, zoo thiab purity yog qhov tseem ceeb, hais tias Dr. Zwickey. "Ib qho yuav tsum yog ib qho tshwj xeeb tshaj plaws txog kev muab khoom ntxiv los ntawm lub tuam txhab kho mob qib qib ntxiv kom ntseeg tau tias kev sim thib peb los ntawm cov tuam txhab muaj koob npe thiab kev lees paub zoo rau [qhov] zoo tshaj [dosing] kev cai," ntxiv Dr. McCubbins.

Nws tseem yog ib qho tseem ceeb kom ntseeg tau tias berberine tau txais txiaj ntsig zoo, raws li Dr. McCubbins. "Goldenseal, txawm tias qhov zoo tshaj plaws ntawm berberine, yog qhov txaus ntshai. Cov tuam txhab ntxiv muaj npe tau paub txog qhov no [qhov teeb meem], ”nws piav qhia. Feem ntau cov ntawv sau ntxiv qhia meej los ntawm cov tshuaj ntsuab twg cov berberine tau muab rho tawm.

Raws li berberine tsis muaj kev tshawb fawb txog kev nyab xeeb mus sij hawm ntev, ib tus yuav tsum sab laj nrog tus kws kho mob ua ntej ntxiv berberine rau lawv cov kev kho mob ntxiv kom ntseeg tau tias nws tsim nyog thiab nyab xeeb rau lawv cov kev xav tau kev noj qab haus huv tshwj xeeb. Yog xav paub ntxiv txog berberine cov txiaj ntsig kev noj qab haus huv, tham nrog tus kws kho mob naturopathic, tus kws kho mob muaj ntawv pov thawj lossis tus kws kho mob acupuncturist.